Background Although previous research suggests that perceptions of stress shape cognitive health outcomes, few studies have explored this association using cognitive domains versus a global measure of cognition, and fewer still have examined blood pressure (BP) as a moderator. Objective We explore whether perceived stress shapes cognitive health outcomes and the influence of BP. Methods Using the Baltimore Study of Black Aging—Patterns of Cognitive Aging, we applied linear regression models to assess whether perceived stress is associated with domain-specific cognitive changes over time and if BP acts as a moderator. Results Findings showed no direct effect of stress on cognitive changes over time. Systolic (F (3346) = 3.00, p = 0.031) and diastolic (F (3346) = 2.63, p = 0.050) BP modified the stress-inductive reasoning relationship but was not related to any other cognitive domains, i.e., working memory, processing speed, verbal memory, and vocabulary at follow-up. Conclusions The findings indicate that stress does not have a direct effect on cognitive change and a fragile interaction between stress and BP on inductive reasoning, such that those with high stress and high BP had high inductive reasoning scores, while those with low stress and high BP had low scores. These results are counterintuitive and require further examination, given that high stress may not be beneficial for people with high BP. Thus, additional research that documents whether stressors have an unforeseen protective effect on domain-specific cognitive decline in Black Americans is needed.
Byrd et al. (Fri,) studied this question.