What does this research mean for the field?

The perillaldehyde-derived compound Y14 suppresses systemic Potato Virus Y (PVY) infection by targeting the viral coat protein at Ser207 to impede intercellular spread. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To identify and characterize a compound that inhibits the spread of PVY by targeting its coat protein.

April 19, 2026

A perillaldehyde‐derived virucide targets phytoviral coat protein at Ser207 to impede intercellular spread

Key Points

To identify and characterize a compound that inhibits the spread of PVY by targeting its coat protein.
Screening for antiviral compounds targeting PVY CP

Structured PICO

Population

Phytoviral (PVY) infection model

Intervention

Compound Y14 (perillaldehyde-derived virucide)

Outcome

Viral intercellular spread and systemic infectionsurrogate

Compound Y14 represents a mechanistically distinctive chemical lead for the management of Potato virus Y (PVY) by targeting its coat protein.

Abstract

This study identifies compound Y14 as an antiviral lead that targets PVY CP and functionally compromises viral intercellular spread, thereby suppressing systemic infection. These findings provide a mechanistically distinctive chemical for PVY management. © 2026 Society of Chemical Industry.

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A perillaldehyde‐derived virucide targets phytoviral coat protein at Ser207 to impede intercellular spread

Key Points

Structured PICO

Abstract

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