The Role of Continuous in situ Targeted Antimicrobials in the Successful Treatment of Extensively-drug Resistant Pseudomonas aeruginosa Left Ventricular Assist Device Driveline Infection – A Case Report

Key Points

• The aim is to explore the effectiveness of continuous in situ targeted antimicrobials in treating LVAD driveline infections caused by drug-resistant bacteria.
• Reported a case of LVAD infection due to extensively drug-resistant Pseudomonas aeruginosa.
• Used systemic antimicrobials combined with CITA and surgical interventions.
• Monitored infection recurrence and response to treatment.
• Achieved successful cure of the recurrent LVAD infection.
• CITA demonstrated effectiveness against biofilm-producing bacteria.
• Highlighted the importance of combined therapeutic strategies for managing complex infections.