What question did this study set out to answer?

The aim is to assess the significance of suspicious bands in serum and urine protein tests among individuals with or without monoclonal gammopathies.

April 21, 2026

Suspicious bands in serum and urine protein immunofixation electrophoresis tests in patients with and without a history of monoclonal gammopathies: a retrospective database study

Key Points

The aim is to assess the significance of suspicious bands in serum and urine protein tests among individuals with or without monoclonal gammopathies.
Conducted a retrospective analysis of patient data from serum and urine protein tests.
Classified patients based on prior history of monoclonal gammopathy.
No patients initially reported with suspicious bands developed monoclonal gammopathy during follow-up.
Recommended separate management protocols for cases based on monoclonal gammopathy history.

Abstract

None of the patients initially reported as having an SfMB developed monoclonal gammopathy during their follow-up period. We recommend that cases reported as "suspicious" be managed separately in patients with and without a prior monoclonal gammopathy diagnosis, where the term "weak positive" may be more appropriate in patients with a known monoclonal gammopathy.

Suspicious bands in serum and urine protein immunofixation electrophoresis tests in patients with and without a history of monoclonal gammopathies: a retrospective database study

Key Points

Abstract

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