Purpose: To compare the 5-year outcome of pterygium excision with Ologen collagen implant versus intra-operative mitomycin C (MMC) adjunct. Methods: This was a comparative study involving 21 eyes with primary pterygium excision done in 2014–2015, 9 of which received Ologen implant and 12 eyes received MMC. Pterygium recurrence, wound bed grading, and anterior segment optical coherence tomography (ASOCT) of the wound bed were evaluated and compared between the two groups. Results: At 5 years after surgery, recurrence occurred in 2 out of 9 eyes in the Ologen group (22.2%) and 0 eyes in the MMC group ( P = 0.147). Apart from one case of Ologen implant dislodgement, there were no other complications in either group. Wound bed grading was significantly higher in the Ologen group ( P = 0.017), with fibrovascular tissue invading the cornea in 44% of eyes. ASOCT showed thicker wound bed measurements at 1 mm and 2 mm postscleral spur in the Ologen group compared to the MMC group ( P = 0.028, 0.002). Conclusion: Intra-operative application of 0.2% MMC in pterygium surgery demonstrated better wound bed outcome with less fibrovascular proliferation, and possibly lower recurrence than Ologen implant. Together with the good safety profile, MMC is the preferred option in primary pterygium excision.
Mok et al. (Wed,) studied this question.