Brain Alterations Linked to the MPTP Mouse Model of Parkinson's Disease Uncovered by Diffusion Kurtosis Imaging and Magnetic Resonance Spectroscopy

Key Points

• To investigate brain alterations using non-invasive imaging in a mouse model of Parkinson's disease.
• Utilized diffusion kurtosis imaging (DKI) and magnetic resonance spectroscopy (MRS) to assess brain changes.
• Applied these imaging techniques to an MPTP mouse model of Parkinson's disease.
• Identified significant neurodegenerative microstructural and neurochemical changes in the brain.
• Demonstrated the effectiveness of DKI and ¹H-MRS in monitoring Parkinson's disease progression.