Selective crystallization of D-mannitol polymorphs in water-isopropyl alcohol through swift cooling process

Key Points

• The research aims to explore the efficient crystallization and separation of D-mannitol polymorphs using a cooling process.
• Utilized a 1:1 (v/v) water-isopropyl alcohol solvent mixture.
• Applied a swift cooling crystallization technique to control polymorphism.
• Assessed the effectiveness of the separation method on different polymorphs.
• Successfully demonstrated the selective crystallization of D-mannitol polymorphs.
• Observed distinct polymorphic forms resulting from the cooling process.
• Achieved improved separation efficiency compared to conventional methods.