Improved bioavailability of raloxifene hydrochloride through nasal administration of poly (methyl vinyl ether-co-maleic acid) nanoparticles in ovariectomized rats. | Synapse
April 22, 2026Open Access
Improved bioavailability of raloxifene hydrochloride through nasal administration of poly (methyl vinyl ether-co-maleic acid) nanoparticles in ovariectomized rats.
Key Points
The central aim is to evaluate the effectiveness of nasal administration of nanoparticles for improving the bioavailability of raloxifene hydrochloride.
Utilization of poly (methyl vinyl ether-co-maleic acid) nanoparticles
Development of a thermoreversible nasal gel formulation
Evaluation in ovariectomized rat models
Nasal administration significantly improved the bioavailability of raloxifene hydrochloride.
The thermoreversible gel was found to be a safe and effective drug delivery system.
Abstract
These results suggest that the thermoreversible nasal gel formulation of RH can be used as a safe drug-delivery system.