Adipose tissue fibrosis in human obesity may limit adipocyte hypertrophy and promote hyperplasia, potentially benefiting systemic metabolism and serving as a therapeutic target.
These data are consistent with the hypothesis that adipose tissue fibrosis in the context of human obesity limits adipocyte hypertrophy and is associated with a reciprocal increase in adipocyte hyperplasia, with beneficial effects on systemic metabolism. These findings suggest adipose tissue fibrosis as a potential target for manipulation of adipocyte metabolism.
Muir et al. (Thu,) studied this question.