What question did this study set out to answer?

To identify how PxJHE2 regulates juvenile hormone and affects fitness costs in Bt-resistant P. xylostella.

April 23, 2026

Down‐regulation of the PxJHE2 gene elevates juvenile hormone titers and compensates for fitness costs of Bt Cry1Ac resistance in Plutella xylostella (L.)

Key Points

To identify how PxJHE2 regulates juvenile hormone and affects fitness costs in Bt-resistant P. xylostella.
Molecular analysis of the PxJHE2 gene
Assessment of juvenile hormone titers
Evaluation of fitness costs related to Cry1Ac resistance.
PxJHE2 is identified as a key regulator of juvenile hormone homeostasis.
Down-regulation of PxJHE2 increases juvenile hormone levels.
Targeting PxJHE2 may enhance Bt pest management strategies.

Abstract

Our findings identify PxJHE2 as a key regulator of JH homeostasis that mediates compensation of fitness costs in Bt Cry1Ac-resistant P. xylostella. Targeting PxJHE2 or its hormonal regulatory pathway may provide a promising strategy to disrupt resistance-associated compensatory mechanisms, thereby enhancing the sustainability of Bt-based pest management programs. These results further provide valuable molecular insights for the development of innovative bioinsecticide strategies. © 2026 Society of Chemical Industry.

Down‐regulation of the PxJHE2 gene elevates juvenile hormone titers and compensates for fitness costs of Bt Cry1Ac resistance in Plutella xylostella (L.)

Key Points

Abstract

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