Background Acrylamide (ACR), used in various food industries, leads to a number of harmful effects, including nephrotoxicity and hepatotoxicity in humans. In this study, we aimed to explore the protective potential of Swertia chirayita against ACR‐induced hepatorenal toxicities and the underlying mechanism in rats. Method Liver and kidney damage was induced using ACR in the male Wistar rats. The ethanolic extract of S. chirayita was used to evaluate the protective effects by analyzing oxidative stress markers, proinflammatory gene expression, and histological changes. Results Experimental results showed that treatment with S. chirayita extract (250 mg/kg and 500 mg/kg) reduced the serum level of liver function markers AST, ALT, ALP, and kidney function markers creatinine and BUN in the ACR rats. Further analysis showed that S. chirayita notably normalized the aberrant level of oxidative stress markers NO, AOPP, and antioxidant enzymes SOD and GSH in the liver and kidney. ACR administration also increased the level of TNF‐α and IL‐1β in the liver and kidney of the ACR rats, which was downregulated by S. chirayita treatment. Histological data revealed that the morphology of the liver and kidney in ACR rats was irregular, and there was a significant accumulation of collagen. Treatment with S. chirayita markedly regularized these changes. Conclusion Our study suggests that the ethanolic extract of S. chirayita has the potential against ACR‐induced hepatorenal damage in rats by balancing oxidative stress and inflammatory response.
Rahman et al. (Thu,) studied this question.