DNA origami-engineered gold nanoparticle multimers for ultrasensitive, label-free SERS detection of small molecules and biomolecules

Key Points

• The aim is to evaluate how DNA origami-engineered gold nanoparticles enhance SERS detection of small and biomolecules.
• Utilized tetrameric plasmonic hotspots constructed from DNA origami.
• Compared the sensitivity of tetramers with dimers for SERS sensing.
• Tetrameric hotspots significantly outperformed dimers in sensitivity.
• Achieved ultralow concentration detection capabilities for small molecules.