Computational investigation of BMS-984923 against Alzheimer’s Amyloid-beta (Ab) structures : Insights into their molecular interactions and inhibition of aggregation

Key Points

• Investigate the molecular interactions of BMS-984923 with Alzheimer's amyloid-beta structures to understand its inhibitory effects.
• Conducted computational studies to simulate molecular interactions with amyloid-beta.
• Analyzed the potential for BMS-984923 to inhibit aggregation of Aβ peptides.
• BMS-984923 demonstrated effective binding to amyloid-beta structures.
• The compound significantly inhibited the formation of oligomers and protofibrils.