Bridging therapy with intravenous alteplase before mechanical thrombectomy resulted in a non-significant increase in 90-day functional independence (42.7%) compared to thrombectomy alone (39.1%).
Observational (n=292)
No
Does bridging therapy with intravenous alteplase before mechanical thrombectomy improve 90-day functional independence in patients with large-vessel ischemic stroke compared to thrombectomy alone?
Bridging therapy with alteplase before mechanical thrombectomy appears safe and may improve functional outcomes in ischemic stroke patients, particularly those under 80 years old treated within 3 hours of symptom onset.
Absolute Event Rate: 42.7% vs 39.1%
Bridging therapy with alteplase before thrombectomy was safe and associated with a modest improvement in functional outcomes compared with thrombectomy alone. The greatest benefit was observed in patients under 80 years old and in those treated within 3 hours of symptom onset. These findings support the continued selective use of alteplase in BT without increasing mortality risk.
Pyza et al. (Thu,) conducted a observational in Ischemic stroke with large intracranial artery occlusion (n=292). Intravenous alteplase (bridging therapy) prior to mechanical thrombectomy vs. Direct mechanical thrombectomy alone was evaluated on Functional independence (mRS ≤ 2) at 90 days. Bridging therapy with intravenous alteplase before mechanical thrombectomy resulted in a non-significant increase in 90-day functional independence (42.7%) compared to thrombectomy alone (39.1%).