What question did this study set out to answer?

This research aims to assess whether direct oral anticoagulants are as effective and safe as warfarin for treating left ventricular thrombus after a heart attack.

April 25, 2026Open Access

D-129 | Direct Oral Anticoagulants are comparable to Warfarin for Post-MI Left Ventricular Thrombus: A Meta-analysis of Randomized Trials

Q: What does this research mean for the field?

Direct oral anticoagulants are comparable to warfarin in efficacy and safety for the management of post-myocardial infarction left ventricular thrombus. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

Key Result

Direct oral anticoagulants are comparable to warfarin for the management of post-myocardial infarction left ventricular thrombus.

Key Points

This research aims to assess whether direct oral anticoagulants are as effective and safe as warfarin for treating left ventricular thrombus after a heart attack.
Conducted a systematic review and meta-analysis of randomized controlled trials (RCTs)
Evaluated the efficacy and safety of direct oral anticoagulants compared to warfarin
Both DOACs and warfarin were found to be similarly effective for managing left ventricular thrombus.
No significant differences in safety profiles between DOACs and warfarin were reported.

Structured PICO

Do direct oral anticoagulants (DOACs) improve efficacy and safety compared to warfarin in patients with post-myocardial infarction (MI) left ventricular thrombus (LVT)?

Population

Patients with post-myocardial infarction (MI) left ventricular thrombus (LVT)

Intervention

Direct oral anticoagulants (DOACs)

Comparator

Warfarin

Outcome

Efficacy and safety

Direct oral anticoagulants are comparable to warfarin for the management of post-MI left ventricular thrombus.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

Direct oral anticoagulants (DOACs) are increasingly used off label for post-myocardial infarction (MI) left ventricular thrombus (LVT) because of lower monitoring burden compared with warfarin. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the efficacy and safety of DOACs versus warfarin for the management of post-MI LVT.