What question did this study set out to answer?

This research aims to assess the prevalence and determinants of anxiety in non-demented ALS patients.

April 26, 2026Open Access

Prevalence and determinants of anxiety in amyotrophic lateral sclerosis

EAEdoardo Nicolò AielloIRCCS Istituto Auxologico Italiano GLGiulia De LucaIRCCS Istituto Auxologico Italiano BCBeatrice CurtiIRCCS Istituto Auxologico Italiano

Key Points

This research aims to assess the prevalence and determinants of anxiety in non-demented ALS patients.
Evaluated anxiety levels in non-demented ALS patients.
Analyzed the relationship between anxiety and depression facets.
Explored independence from motor and cognitive features.
Approximately 18% of ALS patients exhibited significant state-anxiety levels.
Around 14% reported significant trait-anxiety.
Anxiety was primarily influenced by cognitive and affective aspects of depression.

Abstract

Clinically significant levels of state- and trait-anxiety occur in ∼18 and ∼14% of non-demented ALS patients, respectively, mostly driven by cognitive and affective facets of depression, and are independent of motor and cognitive/behavioural features.

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