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August 3, 1995New England Journal of Medicine1,283 citationsOpen Access

A Clinical Trial of Immunosuppressive Therapy for Myocarditis

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JMJay W. MasonJOJohn B. OʼConnellAHAhvie Herskowitz

Structured PICO

Does immunosuppressive therapy improve ventricular function or reduce mortality in patients with myocarditis?

P
Population
Patients with myocarditis
I
Intervention
Immunosuppressive drugs
C
Comparator
No immunosuppressive therapy
O
Outcome
Ventricular function and long-term mortality

Routine treatment of myocarditis with immunosuppressive drugs is not supported, as it does not provide additional benefit for ventricular function.

Abstract

Our results do not support routine treatment of myocarditis with immunosuppressive drugs. Ventricular function improved regardless of whether patients received immunosuppressive therapy, but long-term mortality was high. Patients with a vigorous inflammatory response had less severe disease.

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Cite This Study

Mason et al. (1995) studied this question.

synapsesocial.com/papers/69effb364f6a06657c21e37ahttps://doi.org/10.1056/nejm199508033330501
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