Closed-form multi-region atlas of human miRNA target binding affinity covering 3'UTR, 5'UTR, CDS, and lncRNA regions. 2, 656 mature human miRNAs (miRBase v22) by 19, 542 canonical human protein-coding transcripts (GENCODE v47), with region-appropriate biophysical weakening factors derived in closed form from cellular context (translation rate, scanning ribosome occupancy, cap-binding exclusion). m6A modulation flag via DRACH consensus motif scan (9. 33M sites annotated). Coverage: 2, 656 mature human miRNAs (full miRBase v22 hsa) across up to 5 transcript regions per pair (3'UTR, 5'UTR, CDS, lncRNA, circRNA), with per-site DRACH m6A overlap flag. CDS pipeline is the closed form ribosome displacement three state Markov chain steady-state correction; validation panel n=25 passes all three validation gates with median weakening 2. 60x. 5'UTR pipeline is the closed-form scanning-ribosome displacement with shorter tauₒccupy = 0. 6 s and cap-proximity exclusion mask at d v2 -> v3 progression) - CITATION. cff (machine-readable citation) - clipseqbench/ (CLIP-seq concordance bench: TSVs, JSON, figures, scripts) - drugdesigndemo/ (5 clinical candidates: notebook, recovery TSVs, scripts) - queryₐtlasᵥ3. py (Python helper for atlas queries)
Coracle Research (Thu,) studied this question.