Racemising 3-aryl-3-hydroxy-2-oxindoles in a Pickering emulsion under acid catalysis and its application to dynamic kinetic resolution

Key Points

• To explore a method for racemising 3-aryl-3-hydroxy-2-oxindoles using acid-catalysis in a Pickering emulsion.
• Utilized a water-in-oil Pickering emulsion with toluene and aqueous H2SO4 for racemisation.
• Applied acid-catalysis to facilitate the reaction under biphasic conditions.
• Developed methodology aimed at overcoming decomposition issues during racemisation.
• Successfully racemised 3-aryl-3-hydroxy-2-oxindoles under acid-catalysis.
• The biphasic methodology showed enhanced stability compared to traditional methods.
• Demonstrated effectiveness in dynamic kinetic resolution applications.