Research into auxetic foams—materials with a negative Poisson’s ratio— is expanding, yet their integration into orthotics for diverse neuropathic conditions remains largely unexplored. This pilot study evaluates the feasibility of fabricating custom auxetic foam insoles and characterizing vertical ground reaction force (vGRF) trends across a heterogeneous cohort. In collaboration with the NASA/Marshall Space Flight Center, six participants, including five representing varied neuropathic etiologies and one healthy control, performed randomized walking trials under three conditions: barefoot, over-the-counter (OTC) insoles, and custom auxetic prototypes. The healthy control was retained in the cohort-level analysis to preserve methodological symmetry across experimental conditions. To maintain physical rigor, vGRF data were mass-normalized (N/kg). A Friedman test (n = 6) evaluated global differences, supplemented by a dual-bootstrap analysis (1000 resamples) to quantify effect magnitudes (r) and numerical uncertainty. Although the Friedman test revealed no statistically significant global differences (Q = 0.333, df = 2, p = 0.846), a descriptively large effect size (r = 0.58) was observed for the auxetic material versus barefoot walking. However, wide 95% bootstrap confidence intervals prevent population-level inference, reinforcing the exploratory nature of these findings. Subject-specific observations showed descriptive differences in vGRF in three participants (0.17 to 1.18 N/kg), while increases in others occurred alongside confounding factors such as self-selected walking velocity. This work demonstrates the mechanical application of auxetic insole prototypes, providing a foundational rationale for future trials utilizing standardized walking velocity to isolate material performance.
Batey et al. (Thu,) studied this question.
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