Advanced GC Method for Comprehensive Residual Solvent Analysis: Overcoming Co-elution with Orthogonal Columns and Quantification by Mass Spectrometry | Synapse
To develop a comprehensive gas chromatographic method for identifying residual solvents.
Developed a gas chromatographic method
Targeted 57 residual solvents listed in ICH guidelines
Achieved analysis in a single 30-minute chromatogram
Identified and quantified residual solvents efficiently
Overcame challenges of co-elution with orthogonal columns
Abstract
A robust and comprehensive gas chromatographic method was developed to identify and quantify the 57 residual solvents listed in the ICH guidelines, all in a single, 30-minute chromatogram. The proposed...