Engineering dual-action nitric oxide and propolis releasing polymeric matrix for extended antimicrobial efficacy

Key Points

• To develop a polymeric matrix that releases nitric oxide and propolis to prevent infections associated with indwelling medical devices.
• Developed a dual-action polymeric matrix releasing nitric oxide and propolis
• Evaluated antimicrobial efficacy against common pathogens
• Tested the matrix in simulated indwelling device conditions
• The dual-action polymer exhibited significant antimicrobial activity
• Reduced sepsis incidence in experimental models
• Demonstrated prolonged efficacy compared to conventional treatments