What question did this study set out to answer?

To investigate the correlation between obesity and the size of papillary thyroid carcinoma (PTC).

May 6, 2026Open Access

The relationship of papillary thyroid carcinoma size with overweight or obesity

ADA.1 DinetsNational Academy of Medical Sciences of Ukraine ILI. LurinTaras Shevchenko National University of Kyiv MGM. GorobeikoNational Academy of Agrarian Sciences of Ukraine

Key Points

To investigate the correlation between obesity and the size of papillary thyroid carcinoma (PTC).
Retrospective analysis of 91 patients with histologically confirmed PTC
Categorized patients by BMI into normal weight, overweight, and obese
Statistical analysis performed using Statistica and GraphPad Prism
71% of patients with PTC were overweight or obese
Larger tumors (≥1 cm) predominated in the obese and overweight groups
Microcarcinomas (<1 cm) were more frequent in patients of normal weight

Abstract

Cite in English in Vancouver style: Dinets A, Lurin I, Gorobeiko M, Hoperia V, Abdalla K, Lovin A. The relationship of papillary thyroid carcinoma size with overweight or obesity. Experimental and Clinical Medicine. 2025;94(2):97-104. https://doi.org/10.35339/ekm.2025.94.2.dlg Archived: https://doi.org/10.5281/zenodo.17542394 Abstract Papillary Thyroid Carcinoma (PTC), a well-differentiated malignant neoplasm originating from thyroid follicular cells, has been increasingly studied for its association with obesity. In Ukraine, PTC accounts for approximately 1.7–1.8% of all malignant tumors. Accumulated evidence suggests that obesity, characterized by a Body Mass Index (BMI) over 30 kg/m2, promotes carcinogenesis through hormonal changes, chronic inflammation, oxidative stress, and insulin resistance. The aim of the study was to investigate the relationship of obesity or overweight with PTC size. This retrospective study examined 91 patients with histologically confirmed PTC, categorizing them based on BMI into normal weight, overweight, and obese groups. Patients were divided into groups in relation to their weight. The study group comprised patients with overweight and obesity based on their BMI. Informed consent was obtained from all participants. Statistica 12 (TIBCO Software Inc., USA) and GraphPad Prism 10 (GraphPad Software, LLC, USA) statistical software were used for data analyses. Statistical significance was set at p1 см) частіше зустрічалися в групах з ожирінням та надмірною вагою, тоді як мікрокарциноми частіше зустрічалися у пацієнтів з нормальною вагою. Результати дослідження свідчать, що ПКЩЗ з діаметром пухлини >1 см більш вірогідний у пацієнтів з ожирінням та надмірною вагою. Мікрокарциноми щитоподібної залози більш притаманні пацієнтам з нормальною вагою. Ожирінням можна розглядати як фактор ризику швидшого росту новоутворень при ПКЩЗ. Ключові слова: папілярна мікрокарцинома щитоподібної залози, онкологічний ризик, індекс маси тіла, стадіювання пухлини, прогностичні фактори, морфометричні параметри.

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