Abstract Purpose To present the World Health Organization’s (WHO) multi‑stage methodology used in the 2024 Compendium of Innovative Health Technologies for Low‑Resource Settings and provide a replicable framework for decision‑makers. Methods Α five‑step process is described covering call preparation, open call and screening, multi‑domain assessment, cross‑checking and final approval, and selection. Evidence‑based assessments were conducted across six areas—clinical need, comparison with WHO technical specifications (MeDevIS), regulatory status (WHO/IMDRF), health technology assessment (HTA), health technology management (HTM), and intellectual property 62 technologies underwent full evaluation by multidisciplinary external panels. Following deliberation and validation, 28 technologies were listed (13 commercially available, 3 newly commercialized, 4 prototypes, 1 reassessment, and 7 minor updates), reflecting transparent criteria and consensus‑driven decisions. Conclusions The WHO methodology operationalizes rigorous, transparent, and context‑appropriate evaluation of health technologies for low‑resource settings. By integrating clinical, regulatory, economic, managerial, and IP/LP perspectives, it supports adoption decisions that balance effectiveness, feasibility, and sustainability. The standardized tools and workflows are readily adaptable by ministries of health and procurement bodies to strengthen technology selection processes.
Dermitzakis et al. (Thu,) studied this question.