Persistent lipoprotein(a) exposure and its association with clinical outcomes after acute myocardial infarction: a longitudinal cohort study

AIMS: To assess the link between persistent lipoprotein(a) Lp(a) exposure levels and clinical outcomes in patients with acute myocardial infarction (AMI). METHODS: ). Multivariate Cox regression, subgroup analysis and sensitivity analysis assessed the association between Lp(a) trajectories and major adverse cardiovascular and cerebrovascular events (MACCE), cardiovascular death, non-fatal MI, non-fatal stroke, unplanned revascularization, and all-cause death. RESULTS: , 2.163; 95% CI: 1.405-3.331), compared to the persistent low Lp(a) group. CONCLUSIONS: In AMI patients, sustained high Lp(a) levels were significantly associated with increased risk of MACCE, non-fatal stroke, unplanned revascularization, and both all-cause and cardiovascular death.