What question did this study set out to answer?

The aim is to evaluate the sedative effects of NH600001 compared to etomidate and its impact on adrenocortical function.

May 7, 2026Nature Communications0 citationsOpen Access

NH600001, an etomidate analogue, provides gastrointestinal endoscopy sedation/anesthesia and reduces adrenocortical depression: two randomized controlled trials

YZYingyong ZhouCentral South University KDKaiming DuanCentral South University SLShichao LuoCentral South University

Key Points

The aim is to evaluate the sedative effects of NH600001 compared to etomidate and its impact on adrenocortical function.
Conducted two randomized controlled trials to compare NH600001 with etomidate in gastrointestinal endoscopy sedation.
Performed in Changsha, China, with clinical trial identifiers ChiCTR2300069841 and ChiCTR2400084095.
NH600001 provided significantly higher sedation levels compared to etomidate (P < 0.001).
NH600001 demonstrated a comparable safety profile and resulted in fewer myoclonus adverse events than etomidate.

Abstract

in the NH600001 group, versus the etomidate group, were significantly higher (P < 0.001). Furthermore, NH600001 had a safety profile comparable to etomidate and elicited fewer myoclonus adverse events. In Conclusions, NH600001 has a sedative/anesthetic effect comparable to etomidate while reducing the risk of adrenocortical depression with a favorable safety profile. Chictr.org.cn identifier: ChiCTR2300069841, ChiCTR2400084095. Clinical Trial Number and Registry URL: NH60001-21, Identifier, ChiCTR2300069841 (Changsha, China;, principal investigator: Wen Ouyang, first registration date: March 28, 2023), https://www.chictr.org.cn; NH60001-31, Identifier, ChiCTR2400084095 (Changsha, China, principal investigator: Wen Ouyang, first registration date: May 10, 2024), https://www.chictr.org.cn.

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