This study presents a systematic literary review to explore and correlate the Ayurvedic concept of Sleshmaja Krimi Roga with modern understanding of Helicobacter pylori infection. Classical Ayurvedic texts, including Charaka Samhita, Sushruta Samhita, and Ashtanga Sangraha, were analyzed alongside contemporary scientific literature retrieved from databases such as PubMed, Scopus, and standard medical textbooks. The review highlights conceptual similarities between Krimi Roga and H. pylori infection in terms of etiology, pathogenesis, and clinical manifestations. Ayurvedic descriptions of Kaphaja Krimi show notable parallels with gastric colonization by H. pylori, including factors such as impaired digestion (Agnimandya), accumulation of Ama, and involvement of gastrointestinal channels. Modern evidence demonstrates that H. pylori colonizes the gastric mucosa, leading to inflammation, mucosal damage, and a spectrum of clinical conditions ranging from gastritis to peptic ulcer disease and gastric malignancy. The pathogenesis in both systems reflects a progression from initial colonization to inflammatory response and clinical manifestation. Diagnostic approaches and treatment modalities differ; however, both emphasize the importance of eliminating the causative organism and restoring physiological balance. In conclusion, a significant correlation exists between Ayurvedic and modern perspectives, suggesting that traditional concepts may provide valuable insights into the understanding and management of H. pylori-related disorders. This integrative approach may contribute to improved therapeutic strategies and a broader understanding of gastrointestinal diseases.
*1Dr. Sayad Ali, 2Professor Dr. Pranab Jyoti Baishya, 3Dr. Manir Uddin Dewan (Fri,) studied this question.