Declining Incidence of Large Cell Lung Carcinoma in the United States: Effects of WHO Reclassification in a SEER Analysis

= 0.002). Multivariate analysis identified advanced age, male sex and advanced AJCC stage as independent predictors. Lobectomy and extended lobectomy were associated with improved OS, while no chemotherapy was a risk factor.Conclusions1992-2022 US LCLC incidence decline is attributable to diagnostic drift rather than reduced actual disease burden; our study identified sex, age, AJCC stage, surgical resection extent and chemotherapy as OS predictors for LCLC patients. Notably, SEER lacks modern systemic therapy data, precluding unrigorous extrapolation of its chemoradiotherapy findings to current regimens.