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// Pyong-Gon Moon 1 , Jeong-Eun Lee 1 , Young-Eun Cho 1 , Soo Jung Lee 2 , Yee Soo Chae 2 , Jin Hyang Jung 3 , In-San Kim 4 , Ho Yong Park 3 , Moon-Chang Baek 1 1 Department of Molecular Medicine, Cell and Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu 700-422, Republic of Korea 2 Department of Oncology/Hematology, Kyungpook National University Hospital, Daegu 700-721, Republic of Korea 3 Department of Breast n=80). FN levels were significantly elevated (p< .0001) at all stages of BC, and returned to normal after tumor removal. The diagnostic accuracy for FN detection in extracellular vesicles (ELISA method 1) (area under the curve, 0.81; 95% CI, 0.76 to 0.86; sensitivity of 65.1% and specificity of 83.2%) were also better than those for FN detection in the plasma (ELISA method 2) (area under the curve, 0.77; 95% CI, 0.72 to 0.83; sensitivity of 69.2% and specificity of 73.3%) in BC. The diagnostic accuracy of plasma FN was similar in both the early-stage BC and all BC patients, as well as in the two sets. This liquid biopsy to detect FN on circulating EVs could be a promising method to detect early breast cancer.
Moon et al. (Mon,) studied this question.