MSI1-FTHL17C-iron circuit couples metabolic and epigenetic control of pluripotency in mouse embryonic stem cells | Synapse
May 8, 2026Open Access
MSI1-FTHL17C-iron circuit couples metabolic and epigenetic control of pluripotency in mouse embryonic stem cells
Key Points
This research investigates how iron homeostasis and epigenetic factors work together to maintain the pluripotency of mouse embryonic stem cells.
Investigation of the MSI1-FTHL17C-iron axis
Analysis of post transcriptional control mechanisms
Study of epigenetic changes influencing pluripotency
The MSI1-FTHL17C-iron circuit effectively maintains pluripotency in mouse embryonic stem cells.
Significant correlation found between iron levels and post transcriptional regulation outcomes.
Abstract
⁺-TET axis that integrates post transcriptional control of iron homeostasis with epigenetic remodeling to preserve the pluripotent and plastic state of embryonic stem cells.