High admission GDF-15 levels were significantly associated with increased all-cause mortality risk in patients hospitalized with acute heart failure (RR 2.82; 95% CI 2.39-3.32; p < 0.001).
Meta-Analysis (n=3,724)
Do elevated admission circulating GDF-15 levels predict increased mortality in adult patients hospitalized with acute heart failure?
Elevated admission GDF-15 levels are a strong predictor of all-cause mortality in patients with acute heart failure, supporting its potential role in early risk stratification.
Effect estimate: RR 2.82 (95% CI 2.39-3.32)
p-value: p=< 0.001
BACKGROUND: Growth differentiation factor-15 (GDF-15) is a stress-responsive biomarker implicated in inflammation and myocardial injury. Its prognostic value for mortality risk in acute heart failure (AHF) remains uncertain. This meta-analysis evaluated the association between elevated admission circulating GDF-15 levels and subsequent mortality in patients hospitalized with AHF. METHODS: PubMed, Embase, and Web of Science were systematically searched for prospective or retrospective cohort studies and post-hoc trial analyses enrolling adult AHF patients with blood GDF-15 measured on admission. Risk ratios (RRs) for all-cause mortality comparing high versus low GDF-15 categories were pooled using random-effects models incorporating the influence of potential heterogeneity. RESULTS: Ten studies with 3724 patients with AHF were included. Overall, high admission GDF-15 levels were significantly associated with increased mortality risk during follow-up (RR = 2.82, 95% CI: 2.39-3.32; p 0.05). No significant publication bias was detected (Egger's p = 0.59). CONCLUSIONS: Elevated circulating GDF-15 levels at admission are strongly associated with increased mortality risk in patients with AHF, supporting its potential role in early risk stratification.
Jin et al. (Fri,) conducted a meta-analysis in Acute Heart Failure (n=3,724). High admission GDF-15 levels vs. Low GDF-15 categories was evaluated on All-cause mortality (RR 2.82, 95% CI 2.39-3.32, p=< 0.001). High admission GDF-15 levels were significantly associated with increased all-cause mortality risk in patients hospitalized with acute heart failure (RR 2.82; 95% CI 2.39-3.32; p < 0.001).