Surgical debulking and postoperative multimodal therapy did not prevent disease progression in an 18-year-old male with primary cardiac angiosarcoma, who died 3 months after surgery.
Case Report (n=1)
Primary cardiac angiosarcoma is a rare, highly aggressive malignancy with a poor prognosis that should be considered in young patients presenting with unexplained pericardial effusion or right atrial masses.
Abstract Primary cardiac angiosarcomas are rare and highly aggressive malignancies that often present with nonspecific clinical features, leading to delayed diagnosis and poor outcomes. An 18-year-old male presented with constitutional symptoms and acute breathlessness and was found to have a large pericardial effusion with a right atrial mass. Initial imaging and transvenous biopsy were inconclusive. Surgical exploration and debulking were performed, and histopathological examination with immunohistochemistry confirmed the diagnosis of primary cardiac angiosarcoma. Despite postoperative multimodal therapy including chemotherapy and radiotherapy, the patient succumbed to the disease 3 months after surgery. Primary cardiac angiosarcoma should be considered in young patients presenting with unexplained pericardial effusion or right atrial masses. Early suspicion, multimodality imaging, and combined therapeutic approaches are crucial, although prognosis remains poor.
Jain et al. (Thu,) conducted a case report in Primary cardiac angiosarcoma (n=1). Surgical debulking and multimodal therapy (chemotherapy and radiotherapy) was evaluated. Surgical debulking and postoperative multimodal therapy did not prevent disease progression in an 18-year-old male with primary cardiac angiosarcoma, who died 3 months after surgery.