The accelerating impacts of the Anthropocene have intensified pressure on marine ecosystems. In this context, cellular aquaculture—the production of blue foods through controlled cell cultivation—has emerged as an essential alternative for mitigating marine biodiversity loss and ensuring global food security. However, its advancement is constrained by a critical trilemma comprising economic viability, textural fidelity, and sensory complexity. This review proposes biophysical convergence as a strategic framework to overcome these bottlenecks, emphasizing the integration of bioprocessing agility with food physics. Recent advances in bio-orchestration, including double-network emulsion gels and adaptive materials designed to emulate adipose tissue rheology, are examined alongside physical engineering strategies such as juiciness design via pulsed field gradient stimulated echo nuclear magnetic resonance (PFG-STE NMR), lipid stabilization using artificial oil bodies (AOBs), and monodisperse lipid structuring through microchannel emulsification (MCE). By integrating biological innovation with physical engineering, this review outlines a roadmap toward a regionally harmonized framework for safe and high-fidelity cellular aquaculture.
Maeng et al. (Thu,) studied this question.