Objectives/Goals: Common mamographic findings, breast arterial calcifications (BAC), are a sex-specific biomarker for cardiovascular disease in women. While less common, BAC is frequently encountered on mammograms in males. This study aims to investigate BAC and its association with cardiovascular risk factors in men. Methods/Study Population: A retrospective single-institution study of male patients with mammography studies was performed between September 1, 2018, and September 3, 2025. Diagnostic mammographic images of male patients from a high-volume breast imaging facility were evaluated for the presence of BAC. BAC severity will be assigned a score based on the Canadian Society of Breast Imaging’s grading system. Unique ICD-10 diagnosis codes from the electronic medical record that have been established as independent risk factors for cardiovascular disease will also be reviewed. Male patients who have a prior history of myocardial infarction, coronary revascularization, stroke, heart failure, peripheral vascular disease, breast cancer, dementia, or chronic dialysis/renal transplant were excluded. Results/Anticipated Results: The study is in process of pulling male mammograms from our institution. Current volume of male mammograms at the institution is about 160 male mammograms performed per month. Therefore, we anticipate having around 13,600 male mammograms to analyze the BAC presence. Anticipated results include that patients with independent cardiovascular risk factors such as increased systolic blood pressure, increased LDL levels, and current smokers will have a higher prevalence of BAC presence. Additionally, those with a presence of BAC will be older compared to those that have an absence of BAC on mammography. If BAC is shown to be a significant risk factor for the development of cardiovascular disease, perhaps a mammogram might be recommended in men purely for cardiovascular risk assessment. Discussion/Significance of Impact: A significant association between the presence of BAC and CVD risk factors may provide a supplementary assessment of CVD risk among men, offering a novel tool for risk stratification. Implementing a standardized BAC reporting model may allow for earlier identification of asymptomatic patients at high risk for adverse cardiac events.
Dave et al. (Wed,) studied this question.