Objectives/Goals: Institutional clinical trial accrual metrics and associated monitoring practices are insufficiently characterized and lack consistency. We aim to assess current metrics and methodologies to inform the development of a tool and recommendations that institutions can use to strengthen monitoring capabilities and enhance trial performance. Methods/Study Population: We designed a survey to assess how CTSA institutions measure and monitor clinical trial accrual, including the types of data elements captured, collection methods, and institutional responses to low accrual. Existing survey instruments were reviewed to inform the development of an initial survey. Subject matter experts were consulted on survey questions, sampling strategies, and administration methods. The finalized survey will be distributed to representatives from CTSA institutions. Findings will inform the development of a self-evaluation tool and recommendations to identify gaps and support institutions in strengthening accrual monitoring practices. Results/Anticipated Results: We will disseminate the final survey to CTSA institutions in 2026. We anticipate variability in accrual metrics and monitoring practices within and across institutions nationally. Discussion/Significance of Impact: Further work is needed to establish consistent definitions, collection methods, and reporting frameworks to improve accrual evaluation and address trial pipeline challenges. Without standardization, harmonizing trial data across sites is difficult, limiting opportunities for shared learning.
Moellner et al. (Wed,) studied this question.