Intermolecular Formal Cycloaddition of Indoles with Bicyclo1.1.0butanes by Lewis Acid Catalysis

Herein, we develop a new approach to directly access architecturally complex polycyclic indolines from readily available indoles and bicyclo1.1.0butanes (BCBs) through formal cycloaddition promoted by commercially available Lewis acids. The reaction proceeded through a stepwise pathway involving a nucleophilic addition of indoles to BCBs followed by an intramolecular Mannich reaction to form rigid indoline-fused polycyclic structures, which resemble polycyclic indole alkaloids. This new reaction tolerated a wide range of indoles and BCBs, thereby allowing the one-step construction of various rigid indoline polycycles containing up to four contiguous quaternary carbon centers.