Synthesis, cholinesterase/MAO-A inhibition, antioxidant potential and detailed computational analysis of 3,5-difluorobenzenesulfonate-tagged ethoxyvanillin hydrazones

Key Points

• This research aims to evaluate the inhibitory effects of new hydrazones on cholinesterases and monoamine oxidase-A while assessing their antioxidant potential.
• Synthesized a series of 3,5-difluorobenzenesulfonate-tagged ethoxyvanillin hydrazones.
• Assessed inhibitory activity against acetylcholinesterase, butyrylcholinesterase, and monoamine oxidase-A.
• Evaluated antioxidant activity through specific assays.
• The hydrazones showed significant inhibitory activity against AChE and MAO-A.
• Antioxidant potential was confirmed, indicating protective effects under oxidative stress conditions.