Design, synthesis and evaluation of novel nitroxide-gentiopicroside hybrids as anti-inflammatory agents with free radical scavenging activity

Key Points

• The aim is to develop novel nitroxide-gentiopicroside hybrids with anti-inflammatory properties and the ability to scavenge free radicals.
• Designed and synthesized nitroxide-gentiopicroside hybrids.
• Evaluated anti-inflammatory effects and radical scavenging activity experimentally.
• The new hybrids showed significant anti-inflammatory effects compared to controls.
• Enhanced free radical scavenging activity was observed, suggesting effective ROS modulation.