Catalyst-Free Synthesis of α-Carboline Derivatives via Chromone Skeleton Remodeling

Key Points

• This research focuses on developing a catalyst-free method to synthesize α-carboline derivatives using chromone structures.
• Catalyst-free [3+3] annulation of indolin-2-imines with 3-formylchromones was conducted.
• The chromone undergoes ring-opening followed by reorganization to form α-carboline derivatives.
• Successfully synthesized functionalized α-carboline derivatives through the proposed method.
• Demonstrated the viability of chromone remodeling without the use of catalysts.