Does the level of blood flow alteration during embryonic development affect the manifestation of specific cardiac phenotypes?
Altered blood flow during embryonic development exhibits a dose-response relationship with the manifestation of specific congenital heart defects.
Congenital heart defects result from genetic anomalies, teratogen exposure, and altered blood flow during embryonic development. We show here a novel "dose-response" type relationship between the level of blood flow alteration and manifestation of specific cardiac phenotypes. We speculate that abnormal blood flow may frequently underlie congenital heart defects.
Midgett et al. (Fri,) studied this question.
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