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OBJECTIVE: To provide an overview of the pathology and molecular pathogenesis of traditional serrated adenomas (TSA). DESIGN: Describe the morphology and molecules that play a role in their pathogenesis. RESULTS: wild type and arise by as yet unknown molecular events. All TSAs show retention of mismatch repair proteins. CONCLUSION: These are characteristic unusual polyps with a complex molecular landscape.
McCarthy et al. (Mon,) studied this question.