Does the combination of amyloid deposits and fibrosis on left ventricular endomyocardial biopsy better explain increased extracellular volume at cardiac magnetic resonance and circulating biomarkers than amyloid extent alone in cardiac amyloidosis?
Both amyloid deposits and fibrotic tissue contribute to the enlargement of extracellular spaces in cardiac amyloidosis, better explaining CMR extracellular volume and biomarker levels than amyloid alone.
=0.002) serum levels. Conclusions Extracellular spaces in cardiac amyloidosis are enlarged to a similar extent by amyloid deposits and fibrotic tissue. Their combination can better explain the increased extracellular volume at cardiac magnetic resonance and circulating biomarkers than amyloid extent alone.
Pucci et al. (Fri,) studied this question.