Calmodulin inhibitors chlorpromazine and calmidazolium cause calcium overload and oxidative stress despite reducing peak density of CaV1.2 current in ventricular myocytes

Key Points

• This research aims to explore how calmodulin inhibitors affect calcium dynamics and oxidative stress in heart cells.
• Utilized calmodulin inhibitors chlorpromazine and calmidazolium in experiments
• Measured peak density of CaV1.2 current in ventricular myocytes
• Assessed levels of calcium overload and oxidative stress
• Both inhibitors reduced peak density of CaV1.2 current while causing significant calcium overload.
• Emergence of oxidative stress markers was observed following application of the inhibitors.
• Impairments in cellular function were noted despite the reduction in CaV1.2 current density.