Serum GLP-1 concentrations demonstrated excellent predictive ability for postoperative intestinal ischemia at 24 hours after complete declamping (AUC 0.993).
Cohort (n=80)
No
Can perioperative serum GLP-1 concentrations predict postoperative intestinal ischemia in patients undergoing elective abdominal aortic surgery?
Perioperative serum GLP-1 concentrations show excellent diagnostic accuracy as an early predictive biomarker for postoperative intestinal ischemia following abdominal aortic surgery.
Effect estimate: AUC 0.993
p-value: p=<0.02
BACKGROUND: Acute intestinal ischemia is a severe postoperative complication of abdominal aortic surgery, and delayed diagnosis markedly limits therapeutic options. At present, no reliable biochemical marker for early detection is available. This study assesses whether perioperative changes in glucagon-like peptide-1 (GLP-1) may serve as an early biomarker of postoperative intestinal ischemia. METHODS: This prospective single-centre cohort study enrolled 80 patients undergoing elective abdominal aortic surgery. Total serum GLP-1 concentrations were measured at eight perioperative time points spanning the preoperative, intraoperative, and postoperative periods. Intestinal ischemia was diagnosed using contrast-enhanced magnetic resonance imaging or surgical confirmation. RESULTS: The perioperative time course of GLP-1 was similar across all patients, with peak concentrations consistently observed 24 hours after complete declamping during vascular reconstruction. Six patients developed intestinal ischemia; these individuals exhibited significantly higher GLP-1 levels at all postoperative time points compared with patients without ischemia (p<0.02). GLP-1 demonstrated the highest predictive ability at 24 hours after complete declamping (AUC 0.993); similarly, measurements obtained at 6 hours after complete declamping exhibited excellent predictive performance (AUC 0.919). CONCLUSIONS: Perioperative elevation of GLP-1 demonstrates high specificity for intestinal ischemia, independent of diabetes mellitus or age. Serum GLP-1 concentrations show promise as reliable predictive biomarkers for postoperative intestinal ischemia, with the best diagnostic accuracy observed at 6 and 24 hours after complete declamping during vascular reconstruction.
Tomandlová et al. (Fri,) conducted a cohort in postoperative intestinal ischemia after abdominal aortic surgery (n=80). Serum GLP-1 concentration vs. Patients without ischemia was evaluated on Predictive ability of GLP-1 for intestinal ischemia at 24 hours after complete declamping (AUC 0.993, p=<0.02). Serum GLP-1 concentrations demonstrated excellent predictive ability for postoperative intestinal ischemia at 24 hours after complete declamping (AUC 0.993).