Fractional flow reserve demonstrated higher discrimination ability than instantaneous wave-free ratio for the presence of ≥ 3 high-risk plaque characteristics (AUC 0.703 vs. 0.648, P = 0.045).
Observational
Does fractional flow reserve (FFR) demonstrate different predictability for high-risk plaque characteristics compared to instantaneous wave-free ratio (iFR)?
FFR is independently associated with qualitative high-risk plaque characteristics and shows higher predictive ability for the presence of multiple high-risk features compared to iFR.
Effect estimate: AUC 0.703 vs 0.648
p-value: p=0.045
or plaque burden ≥ 70%) and qualitative features (low attenuation plaque, positive remodeling, napkin ring sign, or spotty calcification). Vessels with FFR ≤ 0.80 or iFR ≤ 0.89 had significantly higher proportions of HRPC than those with FFR > 0.80 or iFR > 0.89, respectively. FFR was independently associated with both quantitative and qualitative HRPC, but iFR was only associated with quantitative HRPC. Both FFR and iFR were significantly associated with the presence of ≥ 3 HRPC, and FFR demonstrated higher discrimination ability than iFR (AUC 0.703 vs. 0.648, P = 0.045), which was predominantly driven by greater discriminating ability of FFR for quantitative HRPC (AUC 0.832 vs. 0.744, P = 0.005). In conclusion, both FFR and iFR were significantly associated with CCTA-derived HRPC. Compared with iFR, however, FFR was independently associated with the presence of qualitative HRPC and showed a higher predictive ability for the presence of ≥ 3 HRPC.
Lee et al. (Mon,) conducted a observational in High-risk plaque characteristics. Fractional flow reserve (FFR) vs. Instantaneous wave-free ratio (iFR) was evaluated on Presence of ≥ 3 high-risk plaque characteristics (HRPC) (AUC 0.703 vs 0.648, p=0.045). Fractional flow reserve demonstrated higher discrimination ability than instantaneous wave-free ratio for the presence of ≥ 3 high-risk plaque characteristics (AUC 0.703 vs. 0.648, P = 0.045).