Age- and sex-specific diagnostic criteria for diastolic dysfunction better predicted incident cardiovascular disease, with moderate-severe dysfunction showing a 65% higher risk (95% CI 1.14-2.38).
Cohort (n=6,102)
Do age- and sex-specific diagnostic criteria for left ventricular diastolic dysfunction improve the prediction of incident cardiovascular disease compared to single cut point criteria in a community cohort?
Age- and sex-specific echocardiographic criteria for diastolic dysfunction are more robustly associated with incident cardiovascular disease than traditional single cut point criteria.
Effect estimate: HR 1.65 (95% CI 1.14-2.38)
BACKGROUND: Left ventricular diastolic dysfunction (DD) is common, particularly in women and older individuals, and it is associated with adverse cardiovascular outcomes. We evaluated the impact of age- and sex-specific diagnostic criteria on the assessment of DD in the community-based Framingham Heart Study. METHODS AND RESULTS: We estimated age- and sex-specific reference limits for echocardiographic measures of DD in a healthy reference subsample (N=2355, mean age 44 years, 66% women). The prevalence, correlates, and association with future cardiovascular disease were compared for DD using age- and sex-specific versus single cut point reference limits in a broad sample (N=6102, mean age 50 years, 56% women). Using age- and sex-specific criteria, DD was present in ≈25% to 30% of individuals across age groups, and it was directly associated with a number of modifiable risk factors. In contrast, with single cut point criteria, age was the primary determinant of DD. During follow-up (mean 7.9±2.2 years), incident cardiovascular disease occurred in 213 of 5770 individuals. Using age- and sex-specific criteria, mild and moderate-severe DD were associated with 50% (95% confidence interval, 1.09-2.05) and 65% (95% confidence interval, 1.14-2.38) higher incidences of cardiovascular disease, respectively, in age- and sex-adjusted analyses. With single cut point criteria, moderate-severe DD (hazard ratio, 1.66; 95% confidence interval, 1.05-2.61), but not mild DD (hazard ratio, 0.94; 95% confidence interval, 0.63-1.40), was associated with incident cardiovascular disease. CONCLUSIONS: Age- and sex-specific reference limits may result in DD assessments that are less dependent on age, more robustly related to modifiable risk factors, and are more closely associated with incident cardiovascular disease.
Nayor et al. (2018) conducted a cohort in Left ventricular diastolic dysfunction (n=6,102). Age- and sex-specific diagnostic criteria vs. Single cut point reference limits was evaluated on Incident cardiovascular disease (HR 1.65, 95% CI 1.14-2.38). Age- and sex-specific diagnostic criteria for diastolic dysfunction better predicted incident cardiovascular disease, with moderate-severe dysfunction showing a 65% higher risk (95% CI 1.14-2.38).