Administration of the IL-1 receptor antagonist anakinra was evaluated for improving peak aerobic exercise capacity and rehospitalization in recently decompensated systolic heart failure (P=0.10).
RCT
Does IL-1 receptor antagonist (anakinra) inhibit the inflammatory response and improve peak aerobic exercise capacity in patients with recently decompensated systolic HF?
p-value: p==0.10
BACKGROUND: An enhanced inflammatory response predicts worse outcomes in heart failure (HF). We hypothesized that administration of IL-1 (interleukin-1) receptor antagonist (anakinra) could inhibit the inflammatory response and improve peak aerobic exercise capacity in patients with recently decompensated systolic HF. METHODS AND RESULTS: =0.10). CONCLUSIONS: and rehospitalization for HF. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT01936909.
Tassell et al. (Wed,) conducted a rct in recently decompensated systolic heart failure. anakinra (IL-1 receptor antagonist) was evaluated on peak aerobic exercise capacity (p==0.10). Administration of the IL-1 receptor antagonist anakinra was evaluated for improving peak aerobic exercise capacity and rehospitalization in recently decompensated systolic heart failure (P=0.10).
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