What question did this study set out to answer?

This study aims to evaluate the schistosomicidal activity of nitazoxanide against different stages of Schistosoma mansoni and its interaction with praziquantel.

May 15, 2026Acta Parasitologica0 citationsOpen Access

Nitazoxanide Exhibits Schistosomicidal Activity Against Schistosomula and Adult Schistosoma mansoni and Influences Praziquantel-Associated Outcomes

CCCícero Jádson da CostaFundação Oswaldo Cruz JGJuliana Ellen de Melo GamaFundação Oswaldo Cruz ASAlex José de Melo SilvaFundação Oswaldo Cruz

Key Points

This study aims to evaluate the schistosomicidal activity of nitazoxanide against different stages of Schistosoma mansoni and its interaction with praziquantel.
Evaluated the efficacy of nitazoxanide and praziquantel against schistosomula and adult stages of Schistosoma mansoni.
Assessed the outcomes of praziquantel treatment in the presence of nitazoxanide.
Praziquantel completely eliminated adult worms, confirming its efficacy.
Nitazoxanide exhibited relevant but lower schistosomicidal activity against schistosomula and adult worms.
Study emphasizes the need for further bioavailability investigations.

Abstract

. Although praziquantel resistance has been reported, in this study it fully eliminated adult worms, while nitazoxanide showed lower but relevant activity against both schistosomula and adult stages. These findings confirm the efficacy of praziquantel against adult worms and highlight therapeutic potential of nitazoxanide, underscoring the need for further bioavailability studies.

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Cite This Study

Costa et al. (Wed,) studied this question.

synapsesocial.com/papers/6a06b86ae7dec685947aae44 https://doi.org/https://doi.org/10.1007/s11686-026-01269-2

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