The Usefulness of Functional Near-Infrared Spectroscopy for the Assessment of Post-Stroke Depression

Q: What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Post-stroke depression (n=45). Intervention: Functional near-infrared spectroscopy (fNIRS) during verbal fluency task vs. Non-depressed post-stroke patients. Primary outcome: oxy-Hb integral values during the activation task period (p=0.040).

Key Result

Functional near-infrared spectroscopy revealed that patients with post-stroke depression had significantly lower oxy-Hb integral values in the frontal lobe compared to non-depressed patients.

Study Design

Type

Cross-Sectional (n=45)

Multicenter

Structured PICO

Does fNIRS measurement of oxy-Hb correlate with post-stroke depression severity in stroke survivors?

Population

45 patients with stroke (26 cerebral infarction, 19 cerebral hemorrhage), >1 month post-onset, mean age 67.8 years, 32 male, MMSE ≥24, admitted to Nagasaki Kita Hospital.

Intervention

Measurement of oxygenated hemoglobin (oxy-Hb) using functional near-infrared spectroscopy (fNIRS) during a verbal fluency task (VFT).

Comparator

Non-depressed stroke patients (n=32) compared to depressed stroke patients (n=13) based on HAMD17 scores.

Outcome

Correlation between oxy-Hb integral values and HAMD17 total scores, and difference in oxy-Hb integral values between depressed and non-depressed groups.surrogate

Measurement of oxy-Hb using fNIRS during a verbal fluency task may be a useful objective methodology for diagnosing post-stroke depression.

Main Result

Absolute Event Rate: 1.71% vs 3.16%

p-value: p=0.040

Limitations

NIRS measures hemoglobin concentration changes only as relative values, not absolute values
Relatively low spatial resolution compared to MRI and low cerebral penetration depth
Contributions from extracerebral tissue (skin and skull) may contaminate the NIRS signal
Lack of standard quantification across different NIRS instruments
Small sample size

Abstract

The present study highlights that the measurement of oxy-Hb by using fNIRS is a useful methodology for the diagnosis of PSD in patients after stroke.

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Cite This Study

Koyanagi et al. (Tue,) conducted a cross-sectional in Post-stroke depression (n=45). Functional near-infrared spectroscopy (fNIRS) during verbal fluency task vs. Non-depressed post-stroke patients was evaluated on oxy-Hb integral values during the activation task period (p=0.040). Functional near-infrared spectroscopy revealed that patients with post-stroke depression had significantly lower oxy-Hb integral values in the frontal lobe compared to non-depressed patients.

synapsesocial.com/papers/6a06cb5a964d5135c0d3ce3d https://doi.org/https://doi.org/10.3389/fnhum.2021.680847

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