Positron emission tomography identified significant areas of hibernating myocardium in 52% of imaged patients with ischaemic heart disease and left ventricular ejection fraction ≤30%.
Observational (n=36)
No
What is the prevalence of hibernating myocardium detected by PET in patients with ischaemic heart disease and LVEF <= 30%?
Up to half of patients with ischemic heart disease and severely reduced LVEF have hibernating myocardium, suggesting a large proportion may benefit from revascularization.
OBJECTIVE: Severe impairment of left ventricular (LV) contraction is associated with an adverse prognosis in patients with ischaemic heart disease. Revascularisation may improve the impaired LV contraction if hibernating myocardium is present. The proportion of patients likely to benefit from this intervention is unknown. Therefore, the prevalence of hibernating myocardium in patients with ischaemic heart disease and severe impairment of LV contraction was assessed. DESIGN: From a consecutive series of patients undergoing coronary angiography for the investigation of chest pain or LV impairment, all patients with ischaemic heart disease and an LV ejection fraction (LVEF) < or = 30% were identified. These patients underwent positron emission tomography (PET) to detect hibernating myocardium, identified by perfusion metabolism mismatch. SETTING: A teaching hospital directly serving 500,000 people. RESULTS: Of a total of 301 patients, 36 had ischaemic heart disease and an LVEF < or = 30%. Twenty-seven patients had PET images, while nine patients were not imaged because of emergency revascularisation (three), loss to follow up (one), inability to give consent (four), and age < 50 years (one, ethics committee guidelines). Imaged and non-imaged groups were similar in LV impairment, demographic characteristics, and risk factor profile. Fourteen patients (52% of the imaged or 39% of all patients with ischaemic heart disease and LVEF < or = 30%) had significant areas of hibernating myocardium on PET. CONCLUSION: It is possible that up to 50% of patients with ischaemic heart disease and severely impaired left ventricles have hibernating myocardium.
Al‐Mohammad et al. (Tue,) conducted a observational in Ischaemic heart disease with severely impaired left ventricles (n=36). Positron emission tomography (PET) was evaluated on Prevalence of hibernating myocardium. Positron emission tomography identified significant areas of hibernating myocardium in 52% of imaged patients with ischaemic heart disease and left ventricular ejection fraction ≤30%.